Persons with acute PCR-confirmed COVID-19 should not be vaccinated until after they have recovered from acute illness and the criteria for ending isolation have been met. SAGE has thoroughly assessed the data on quality, safety and efficacy of this vaccine and has recommended its use for people aged 18 and above. In countries with ongoing SARS-CoV-2 transmission, the benefit of vaccination in protecting against COVID-19 far outweighs the risks of TTS. However, benefit–risk assessments may differ from country to country. As part of the EUL process, CanSino has committed to continuing submit data on safety, efficacy and quality in ongoing vaccine trials and rollout in populations, including in older adults. Clinical trial data showed that the Ad5-nCoV vaccine had an efficacy of 58% against symptomatic disease and 92% against severe COVID-19. SAGE recommends the use of Ad5-nCoV vaccine as a single dose (0.5 ml) given intramuscularly into the deltoid muscle.
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