Gp europa 1993. Nacional asuncion x.

gp europa 1993

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In recent decades, cosmetic formulations have been developed and employed in the treatment or prevention of skin changes resulting from aging, such as loss of elasticity, dryness, formation of wrinkles and spots, thus, possible delaying invasive procedures such as plastic surgery. In this context, substances with anti-aging action have been proposed to delay the appearance of wrinkles or leaving them less visible. However, due to the high turnover in the cosmetic area, active substances and their cosmetic products are constantly available to commercial purposes without basic studies on the action mechanisms supporting their benefits ( Hermanns-Lê et al., 2001 HERMANNS-LÊ, T.; JONLETA, F.; SCHEENB, A.; PIÉRARD G.E. Age- and body mass index-related changes in cutaneous shear wave velocity. Exp. Gerontol., v.36, n.2, p. On the other hand, the search in the dermatology area for non-toxic molecules that mimic the action of botulinum neurotoxin, has identified acetyl hexapeptide-3 in a rational design program. An in vitro study demonstrated that acetyl hexapeptide-3 inhibits neurotransmitter release with a potency similar to that of botulinum neurotoxin, although as expected, it displayed much lower efficacy than the neurotoxin ( Sivilia et al., 2008 SIVILIA, S.; PARADISI, M.; D'INTINO, G.; FERNANDEZ, M.; PIRONDI, S,; LORENZINI L, CALZA L. Skin homeostasis during inflammation: a role for nerve growth factor.

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