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Natl. Cancer Inst. doi: 10.1093/jnci/85.3.200. [PubMed] [CrossRef] [Google Scholar] Allred scores are created by summing two separate scores: (the overall intensity of stained cells, none = 0, weak = 1, intermediate = 2, strong = 3) + (percentage of cells staining positive none = 0, Table 2 Relationship of 2-week Ki67 and tumor shrinkage (single dimension RECIST) for IL1839/223 study, anastrozole only to 2 weeks ± gefitinib to 16 weeks, p for trend = 0.0504 and PALLET study (Letrozole only—group A), p for trend = 0.02. Tables 5 and 8 identify the patients who, on the basis of ER/PgR baseline status and on-treatment Ki67, should be considered for longer-term NeoET or conversely should not continue on NeoET. In PALLET + IL1839/223 and ADAPT postmenopausal patients, the proportions of patients who can remain on NeoET are very similar at 86% and 85%, respectively. From the POETIC data, the proportion was a little lower, which was expected, as this is a case-controlled cohort with 50% of the population experiencing a relapse. For POETIC, the overall proportion of patients recommended for on-treatment biopsy was 33% (110/338) if based on Allred scores and 42% if based on %age of cells staining; for PALLET/ IL1839/223 the proportion was 33% (85/257), and for ADAPT postmenopausal patients it was 41% (793/1925). Centres wishing to apply on-treatment Ki67 should confirm that their Ki67 analysis is operating to similar levels and should contact the authorship to access material if needed to do so. Differences in scoring of Ki67 were found by the International KiBCWG to be the most important source of between-laboratory variability. Consistency of scores is markedly enhanced by adherence to the methodology for “global scoring” which was validated and endorsed by the KiBCWG 20 and is advocated here. Italia jogos.O brother saiu com 48,45%% dos votos. Ja Natalia ficou com 26,1% e Jessilane com 25,45%.
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